【摘 要】
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Hand,foot and mouth disease (HFMD) has become a major public health problem in China since 2008,which has been widely prevalent in children under 5 years of age
【机 构】
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Quanzhou Children’s Hospital, Teaching Hospital of Fujian Medical University, Quanzhou, Fujian 36200
论文部分内容阅读
Hand,foot and mouth disease (HFMD) has become a major public health problem in China since 2008,which has been widely prevalent in children under 5 years of age.According to the data of the Ministry of Health,the number of cases with HFMD exceeded 1 million during the recent 4 years.The major etiologic agent of HFMD is enterovirus 71 and coxsackievirus A 16.The main clinical manifestations of the disease include fever,maculopapular skin vesicles on the hand,foot and buttock,oral herpes,ulcer;ation severe cases there can be central nervous system infection and/or pulmonary hemorrhage,which are mostly caused by EV71 and may be life-threatening with a fatality rate of 0.3 to 0.5 per thousand cases.
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