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本文采用双盲法不完全交叉设计,选择年龄60～89岁的健康老年试者158名,随机分配到实验组(低剂量组:每日服锌15mg;高剂量组:每日服锌100mg)对照组(每日服安尉剂),用药期12个月。在研究开始时以及研究的第3、6、12和16个月时,分别抽取静脉血样,测定血浆、红细胞和血小板锌含量,并使用促细胞分裂剂和抗原进行DDH(迟发皮肤过敏性)、LPR(淋巴细胞增殖反应)和NK细胞活性(自然杀伤细胞活性)实验,以评价锌及其他微量营养素(多种维生素和矿物质)对老年人细胞免疫功能的影响。研究过程中,受试者被建议食用含叶酸、维生素B_6、维生素E、Cu、Zn、Mg低的食物,以减少对实验的干扰。
In this paper, double blind method is not completely cross design, select the aged 60 to 89 healthy aged 158 subjects were randomly assigned to the experimental group (low dose group: daily dose of zinc 15mg; high dose group: daily dose of zinc 100mg) Control group (daily serving Wei Wei agent), medication period of 12 months. At the beginning of the study and at months 3, 6, 12 and 16 of the study, venous blood samples were drawn separately and the plasma zinc, erythrocytes and platelets were assayed for zinc and DDH (delayed skin hypersensitivity) using mitogens and antigens , LPR (Lymphocyte Proliferation Response) and NK Cell Activity (Natural Killer Cell Activity) assays to assess the effects of zinc and other micronutrients (vitamins and minerals) on cellular immune function in the elderly. During the study, subjects were advised to eat foods containing folic acid, vitamin B_6, vitamin E, Cu, Zn, Mg low to reduce interference with the experiment.