一种制备手性α-烃基取代甘氨酸盐酸盐的方法,选用已经在市场上商业化或者容易制备的甘氨酸叔丁酯为初始原料,通过手性辅剂(S)樟脑诱导α位手性烃基取代,并进一步通过化学拆分得到光学纯度大于99%的α-烃基取代甘氨酸酯,最后水解得到光学纯的α-烃基取代甘氨酸盐酸盐,其中R为C1~C12的饱和或不饱和烷基或者C1~C12的饱和或不饱和烷基取代的苯基。该方法原料廉价易得,反应 A method for preparing chiral α-hydrocarbyl substituted glycine hydrochloride, the commercially available or readily available glycidyl t-butyl ester is used as a starting material to induce the α-position chiral hydrocarbon group (S) through the chiral auxiliary (S) , And further by chemical resolution an α-hydrocarbyl substituted glycinate having an optical purity of greater than 99% is obtained and finally hydrolyzed to give optically pure α-hydrocarbyl substituted glycine hydrochloride, wherein R is a C1-C12 saturated or unsaturated alkyl Or C1-C12 saturated or unsaturated alkyl-substituted phenyl. The method of raw materials cheap and easy to get reaction