高血压是心血管病及脑卒中发病率及死亡率的危险因素,清晨血压的危险浪潮增加心肌梗死、不稳定型心绞痛、脑卒中和心源性猝死的发生率。提示对高血压患者维持降压药在24h剂量间期,特别是在危险的清晨数小时的有效性之重要。为了评价联合血管紧张素Ⅱ受体抑制剂(ARB)与氢氯噻嗪( Hypertension is a risk factor for cardiovascular morbidity and stroke morbidity and mortality. The dangerous wave of morning blood pressure increases the incidence of myocardial infarction, unstable angina, stroke, and sudden cardiac death. This suggests that it is important to maintain the effectiveness of antihypertensive drugs in patients with hypertension during the 24-hour dose interval, especially during the dangerous morning hours. In order to evaluate the combination of angiotensin II receptor inhibitor (ARB) and hydrochlorothiazide