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rn目的探讨大骨瓣减压术联合脑局部亚低温治疗重型颅脑损伤的临床疗效。方法 64例重型颅脑损伤患者随机均分为两组:A组采用大骨瓣减压术和脑局部亚低温治疗;B组单用大骨瓣减压术。随访3个月,观察两组颅内压变化、并发症及预后。结果 A组术后24、48和72h颅内压显著低于B组(P“,”Objective To investigate the outcomes of treating severe traumatic brain injury(STBI) with combined use of large trauma craniotomy and regional cerebral mild hypothermia.Methods Sixty-four patients with STBI were equally randomized into two groups of A(treated with combined use of large trauma craniotomy and regional cerebral mild hypothermia) and B(treated with large trauma craniotomy alone).The patients were followed up for 3 months and the clinical efficacy,intracranial pressure(ICP) and the prognosis were evaluated.Results The recovery was much better in group A than that in group B.ICP was lower in group A than that in group B at 24,48 and 72 h after treatment(P<0.05).The GOS score in group A was remarkably better than that in group B(P<0.05).Conclusion The treatment of STBI of large trauma craniotomy combined with regional cerebral mild hypothermia is more effective in improving the survival rate and the quality of life.