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目的:探讨奥美拉唑与雷尼替丁治疗非甾体类抗炎药相关性胃溃疡的效果。方法:选取2015年1月至2016年1月期间在该院接受治疗并确诊为非甾体类抗炎药相关性胃溃疡的患者共80例,将所有患者随机分为观察组与对照组两个组别,观察组40例患者给予奥美拉唑进行治疗,对照组40例患者给予雷尼替丁治疗,对比两组患者的胃黏膜损伤与不良反应发生情况。结果:治疗3个月后,观察组患者的治疗有效率为60.00%,明显高于对照组患者的治疗有效率(32.50%,P<0.05);两组患者在治疗期间的不良反应发生率分别为17.50%、37.50%,观察组情况明显优于对照组(P<0.05)。结论:奥美拉唑治疗非甾体类抗炎药相关性胃溃疡的临床效果明显优于雷尼替丁,能促进患者胃黏膜损伤的恢复,减少上消化症状的发生,值得临床推广应用。
Objective: To investigate the effect of omeprazole and ranitidine in the treatment of non-steroidal anti-inflammatory drug-related gastric ulcer. Methods: A total of 80 patients admitted to our hospital from January 2015 to January 2016 for NSAID-related gastric ulcer were enrolled. All patients were randomly divided into observation group and control group Forty patients in the observation group were given omeprazole for treatment. Forty patients in the control group were treated with ranitidine, and the gastric mucosal injury and adverse reactions were compared between the two groups. Results: After 3 months of treatment, the treatment effective rate in the observation group was 60.00%, which was significantly higher than that in the control group (32.50%, P <0.05). The incidence of adverse reactions in the two groups were respectively Was 17.50%, 37.50%, the observation group was significantly better than the control group (P <0.05). Conclusion: Omeprazole is superior to ranitidine in the treatment of nonsteroidal anti-inflammatory drug-related gastric ulcer. It can promote the recovery of gastric mucosal injury and reduce the incidence of upper digestive symptoms, which deserves clinical application.