目的:探讨微刺激促排卵方案在多囊卵巢综合征(PCOS)患者IVF中的应用。方法:将行IVF-ET的不孕患者分为3组:PCOS长方案组(A组,n=31)、PCOS微刺激组(B组,n=23)和非PCOS长方案对照组(C组,n=25)。比较3组的年龄、不孕年限、基础内分泌、口服避孕药后基础内分泌及IVF结局。结果:①年龄、不孕年限、基础FSH(bFSH)组间比较均无统计学差异(P>0.05);bLH、bLH/bFSH、bT在A组和B组中均明显高于C组(P<0.05);用口服避孕药后A组和B组LH、LH/FSH、T明显降低,使3组间内分泌比较无统计学差异(P>0.05)。②A组的受精率、卵裂率低于C组(P<0.05);Gn使用天数、获卵数、可利用胚胎数、优质胚胎数高于C组(P<0.05);Gn使用总量、种植率、临床妊娠率、流产率A、C组间比较均无统计学差异(P>0.05)。③B组受精率、卵裂率低于C组(P<0.05);Gn使用总量及Gn使用天数比C组明显减少(P<0.05);获卵数、可用胚胎数、优质胚胎数高于C组(P<0.05);B、C组间种植率、临床妊娠率、流产率比较无统计学差异(P>0.05)。④B组Gn使用总量及Gn使用天数比A组明显减少(P<0.05);B组获卵数、受精率、卵裂率、优质胚胎数、可利用胚胎数等指标与A组比较均无统计学差异(P>0.05)。⑤B组hCG注射日E2水平及移植日子宫内膜厚度明显低于A组(P<0.05),但种植率、临床妊娠率、流产率等方面与A组比较均无统计学差异(P>0.05)。结论:①口服避孕药在调整PCOS患者内分泌,降低PCOS患者LH、T方面有较好的作用,能改善PCOS患者内分泌环境;②PCOS患者行IVF时采用克罗米酚(CC)加hMG微刺激可降低hCG注射日E2水平,减少OHSS的发生。③CC加hMG微刺激方案对PCOS患者行IVF促排卵可能是相对经济、有效、安全的方法。 Objective: To investigate the application of micro-stimulation ovulation induction in IVF in patients with polycystic ovary syndrome (PCOS). Methods: Infertility patients with IVF-ET were divided into three groups: PCOS long-term group (group A, n = 31), PCOS micro-stimulation group (group B, n = 23) and non-PCOS long-term control group Group, n = 25). The age, duration of infertility, basic endocrine, basic endocrine after oral contraceptives and IVF outcome were compared between the three groups. Results: ① There was no significant difference in age, duration of infertility, basic FSH (bFSH) between the two groups (P> 0.05); bLH, bLH / bFSH and bT in group A and group B were significantly higher than those in group C <0.05). The LH, LH / FSH and T of group A and group B after oral contraceptive use were significantly decreased, which showed no significant difference between the three groups (P> 0.05). (2) The fertilization rate and cleavage rate of group A were lower than that of group C (P <0.05); The number of days of Gn use, the number of oocytes retrieved, the number of available embryos and the number of high quality embryos were higher than those of group C (P <0.05) Implantation rate, clinical pregnancy rate, abortion rate A and C were no significant difference (P> 0.05). (3) The fertilization rate and cleavage rate in group B were lower than those in group C (P <0.05); the total amount of Gn and the number of days of Gn use were significantly lower than those in group C (P <0.05) (P <0.05). There was no significant difference in implantation rate, clinical pregnancy rate and abortion rate between B and C groups (P> 0.05). ④ The total amount of Gn and the number of Gn days in group B decreased significantly (P <0.05) compared with group A; The number of oocytes, fertilization rate, cleavage rate, number of high quality embryos and available embryos in group B were all lower than those in group A Statistical difference (P> 0.05). (5) The level of E2 in group B on the day of hCG injection and the thickness of endometrium on the day of transplantation were significantly lower than those in group A (P <0.05), but the implantation rate, clinical pregnancy rate and abortion rate were not significantly different from those in group A (P> 0.05 ). Conclusions: ① oral contraceptives in the adjustment of endocrine PCOS patients and reduce PCOS patients with LH, T has a good effect, can improve the PCOS patient’s endocrine environment; ② PCOS patients with IVF clomiphene phenol (CC) plus hMG micro-stimulation can Reduce the E2 level on the day of hCG injection and reduce the occurrence of OHSS. ③CC plus hMG micro-stimulation regimen in patients with PCOS IVF ovulation may be a relatively economical, effective and safe method.