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目的 探讨辛伐他汀对糖尿病大鼠肾肥大指数的影响。方法 将实验动物随机分为正常对照组 (A组 )、糖尿病组 (B组 )及辛伐他汀治疗观察组 (C组 )。第二、四、六周分别取各组 5只大鼠收集标本 ,检测血糖、血胆固醇及肾肥大指数的变化。结果 辛伐他汀观察组血胆固醇水平、肾肥大指数均低于糖尿病组。结论 辛伐他汀可以降低糖尿病大鼠肾肥大指数 ,对糖尿病肾脏病变有保护作用。
Objective To investigate the effect of simvastatin on renal hypertrophy index in diabetic rats. Methods The experimental animals were randomly divided into normal control group (group A), diabetic group (group B) and simvastatin treatment group (group C). In the second, fourth and sixth weeks, five rats in each group were collected to detect the changes of blood glucose, blood cholesterol and renal hypertrophy index. Results The levels of serum cholesterol and renal hypertrophy in simvastatin group were lower than those in diabetic group. Conclusion Simvastatin can reduce the renal hypertrophy index of diabetic rats, which has a protective effect on diabetic nephropathy.