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报告7例肥胖患者肾移植的手术治疗及术后恢复情况,并与非肥胖组进行对照,结果肥胖患者手术时间及术中血管吻合时间均明显长于对照组(P<0.05),术后肾功能恢复时间也明显延长(P<0.05),其并发症的发生率也较对照组高.术后第8周时,肥胖组CsA用量虽低于对照组,但血浓度却仍高于对照组(P<0.05).表明肥胖因素对移植手术、术后并发症、免疫抑制剂的应用及肾功能的恢复均有一定的影响.认为由于CsA具有脂肪蓄积作用,其毒性可能影响肾功能恢复,故肥胖患者的CsA用量应低于非肥胖者.
Reported 7 cases of obese patients with renal transplantation surgery and postoperative recovery, and compared with non-obese group, the results of obese patients operating time and intraoperative vascular anastomosis were significantly longer than the control group (P <0.05), postoperative renal function The recovery time was also significantly prolonged (P <0.05), and the incidence of complications was also higher than the control group.At the 8th week after surgery, although the CsA dosage in obese group was lower than that in the control group, the blood concentration was still higher than that in the control group P <0.05), indicating that obesity has certain influence on the transplantation operation, postoperative complications, the application of immunosuppressive agents and the recovery of renal function.It is considered that the CsA has the effect of fat accumulation and its toxicity may affect the recovery of renal function The amount of CsA in obese patients should be lower than in non-obese people.