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目的:分析原发性醛固酮增多症（primary aldosteronism，PA）患者代谢指标及其他特征的变化，提高对PA的认识。方法:选择2017年1月至2020年8月唐山市工人医院明确诊断且符合纳入条件的91例PA患者作为观察对象（PA组），纳入同时期诊断为原发性高血压（essential hypertension，EH）的患者112例作为对照（EH组）。进行回顾性病例对照研究，比较两组患者的血糖、血脂、同型半胱氨酸、血钾、肌酐、尿酸、醛固酮、肾素、血浆醛固酮/肾素浓度比值（aldosterone to renin ratio，ARR），以及血压、腰围等指标的差异。正态分布的计量资料比较采用独立样本n t检验；非正态分布数据以n M（Qn 1，Q3）表示，组间比较采用秩和检验。计数资料比较采用n χn 2检验。多因素分析采用Logistic回归法。n 结果:单因素分析结果显示，PA组患者血钾为（3.37±0.39）mmol/L、肾素为1.61（0.34，7.23）ng/L、ARR为96.85（26.06，506.10），EH组患者血钾为（3.91±0.59）mmol/L、肾素为12.81（1.90，82.45）ng/L、ARR为13.22（1.06，54.63），组间比较差异均有统计学意义（n t=3.35、Z=6.24、Z=55.40，均n P<0.001）。PA组患者收缩压为（190.80±20.30）mmHg、舒张压为（117.70±12.89）mmHg、腰围为（91.67±9.38）cm，EH组患者收缩压为（177.01±12.89）mmHg、舒张压为（101.39±9.34）mmHg、腰围为（86.59±9.07）cm，两组比较差异均有统计学意义（n t=5.88、n t=10.44、n t=3.90，均n P<0.001）。多因素Logistic回归分析结果显示，腰围（n OR=1.065，9n 5% CI为1.007~1.118，n P<0.001）、收缩压（n OR=1.053，9n 5% CI为1.034~1.077，n P<0.001）、舒张压（n OR=1.054，9n 5% CI为1.031~1.077，n P<0.001）、ARR（n OR=1.170，9n 5% CI为1.115~1.228，n P<0.001）为PA的危险因素。n 结论:与EH相比，PA患者血压、ARR及腰围高，血钾及肾素水平低；收缩压、舒张压、ARR、腰围为PA的危险因素。高危人群加强PA的筛查和治疗有利于更好地规避靶器官损害风险。“,”Objective:To analyze the changes of metabolic indexes and other characteristics in patients with primary aldosteronism (PA) and improve the understanding of PA.Methods:From January 2017 to August 2020, 91 PA patients who were clearly diagnosed and met the inclusion conditions in Tangshan workers Hospital, Hebei Medical University were selected as the observation object (PA group), and 112 patients diagnosed as essential hypertension (EH) in the same period were included as the control (EH group). A retrospective case-control study was conducted to compare the differences of blood glucose, blood lipid, homocysteine, blood potassium, creatinine, uric acid, aldosterone, renin, plasma aldosterone to renin ratio (ARR), blood pressure and waist circumference between the two groups. The measurement data of normal distribution were compared by independent sample t-test. The non normal distribution data are represented by M (Qn 1, Qn 3), and the rank sum test is used for inter group comparison. Comparison of counting data n χ2 inspection. Logistic regression was used in multivariate analysis.n Results:Univariate analysis showed that serum potassium, renin and ARR were (3.37±0.39) mmol/L, 1.61 (0.34, 7.23) ng/L and 96.85 (26.06, 506.10) in PA group and (3.91±0.59) mmol/L, 12.81 (1.90, 82.45) ng/L and 13.22 (1.06, 54.63) in EH group (n t=3.35, z=6.24, z=55.40, all n P<0.001). In PA group, systolic blood pressure was (190.80±20.30) mmHg, diastolic blood pressure was (117.70±12.89) mmHg, waist circumference was (91.67±9.38) cm, and in EH group, systolic blood pressure was (177.01±12.89) mmHg, diastolic blood pressure was (101.39±9.34) mmHg, waist circumference was (86.59±9.07) cm. There were significant differences between the two groups (n t=5.88, 10.44, 3.90; all n P<0.001). Multivariate logistic regression analysis showed that waist circumference (OR=1.065, 95% CI 1.007-1.118,n P<0.001), systolic blood pressure (OR=1.053, 95% CI 1.034-1.077,n P<0.001), diastolic blood pressure (OR=1.054, 95% CI 1.031-1.077,n P<0.001), and ARR (OR=1.170, 95% CI 1.115-1.228,n P<0.001) were the risk factors for PA.n Conclusion:Compared with essential hypertension, PA patients have higher blood pressure, ARR and waist circumference, lower blood potassium and renin levels. Systolic blood pressure, diastolic blood pressure, ARR and waist circumference are the risk factors of PA. Strengthening the screening and treatment of PA in high-risk groups is helpful to better avoid the risk of target organ damage.