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几十年来,氢氧化铝和磷酸铝被广泛用作疫苗佐剂,具有良好的安全性。最近在人体三角肌中观察到含氢氧化铝针状物的巨噬细胞聚集体(巨噬细胞肌筋膜炎),引发了人们对铝盐的研究。此项研究旨在进一步搞清疫苗注射部位铝的清除及其所致病理损伤的特征。两组12只重量相近的雄性猕猴分
For decades, aluminum hydroxide and aluminum phosphate have been widely used as vaccine adjuvants with good safety. The recent discovery of aluminum hydroxide needle-containing macrophage aggregates (macrophage myofascitis) in the human deltoid muscle triggered the study of aluminum salts. The aim of this study was to further clarify the characteristics of aluminum clearance and the pathological damage caused by the vaccine at the injection site. Two groups of 12 male cynomolgus monkeys with similar weights