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目前恶性滋养细胞肿瘤的治疗,是以化疗为主,辅以手术、放疗、中药、免疫的综合治疗。下面只就化疗谈点体会。恶性滋养细胞肿瘤对化学药物十分敏感,即使已有广泛转移,化疗也能取得惊人效果。常用化学药物为5—氟脲嘧啶(5FU)、氨甲喋呤(MTX)、更生霉素(KSM)、溶癌呤(AT-1438)、消瘤芥(AT-1258)、长春新碱(VCR)和盐酸氮芥(NH_2)等。通常多为5FU及KSM联合用药,也有用KSM和AT-1258联合化疗,单药化疗则常用5FU或MTX,此外还有序贯化疗、多药化疗等,其中以联合化疗为佳。药物剂量:各药治疗必须达到病人最大耐受量,尤其是第一、第二疗程更为关键。如药量不足,不但
At present, the treatment of malignant trophoblastic tumors is based on chemotherapy, combined with surgery, radiotherapy, traditional Chinese medicine, immunotherapy. The following talk about chemotherapy experience. Malignant trophoblastic tumors are very sensitive to chemotherapeutics, and even with extensive metastases, chemotherapy can achieve dramatic results. Commonly used chemical drugs are 5-fluorouracil (5FU), methotrexate (MTX), dactinomycin (KSM), carotenoids (AT- 1438), Adenomyosis (AT- 1258), vincristine (VCR) and Nitrogen mustard (NH_2) and so on. Usually more than 5FU and KSM combination therapy, but also useful combination of KSM and AT-1258 chemotherapy, monotherapy is commonly used 5FU or MTX, in addition to sequential chemotherapy, multi-drug chemotherapy, which combined chemotherapy is better. Drug Dosage: Each drug treatment must reach the maximum patient tolerance, especially the first and second course of treatment is more critical. Such as lack of medication, not only