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自从1975年 Milstein 与 Kohler 首创的单克隆技术问世以来,BALB/C 小鼠是目前国内外研究单克隆抗体比较理想而应用较多的动物。它起源于美国东部小镇 Ohio,1923年开始作近交培育,1932年达到26代。之后snell 将 BALB—加 C。小写英文字母 c 是毛色隐性上位基因(表示白化)。此鼠为白化株。毛色基因型 AAbbcc。平均寿命雄性509天,雌性561天。每胎产仔数1—10只,平均5只。性情温顺,雄鼠不爱斗架。我们实验室引进的 BALB/C 小鼠是按照四军大动物所资料饲养的。以下是几点体会:
Since the advent of monoclonal technology pioneered by Milstein and Kohler in 1975, BALB / C mice are the most ideal and widely used monoclonal antibodies in research at home and abroad. It originated in Ohio, the eastern town of the United States, began to make inbreds in 1923 and reached the 26th generation in 1932. After snell BALB- plus C. Lowercase English letter c is covert coat epistasis gene (that whitening). This mouse is albino. Coat color genotype AAbbcc. The average life expectancy of 509 males, females 561 days. The number of litters per litter is 1-10, with an average of five. Gentle temperament, male rats do not love bucket rack. The BALB / C mice introduced in our laboratory are bred according to the data of the Big Four. Here are some experiences: