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患儿男,10岁。因持续高热1周于1993年9月4日就诊,1周来体温39～40℃,昼低夜高,轻咳咽痛,无吐泻。曾在院外诊治,用过青霉素、氨苄青霉素、头孢氨苄等热未退。既往无药物过敏史。体检:T39.5℃,急性热病容,神软气平,咽部充血,扁桃腺肿大Ⅱ度,无分泌物,心肺听诊无异常。实验室检查:白细胞18×10~9/L,N0.8,L0.2。胸透、大小便常规均正常。拟诊“发热待查”。予氨苄青霉素、头孢环己烯静脉滴注。用10％葡萄糖液(浙江新昌制药厂生产。批号9302102)将头孢环己烯(杭州民生制药厂生产,批号930518)稀释成2.5％浓度,以每分钟30滴的速度滴入约2～3分钟,患儿即全身散发对称性红斑疹。当即肌注非那根针25mg,并减慢滴速。片刻,皮疹增多融合成猩红热样疹,患儿诉胸闷、恶心,立即停药。体检,BP10/6kPa,气促酒醉貌,恐惧不安,口唇紫绀,肢端紫冷,脉细软无力,心律120次/分,心音低钝,呼吸46次/分,两肺呼吸音粗。立即吸氧,静注0.001％肾上腺素3ml、地塞米松5ml。约10分钟紫绀减轻,BPl2.7/9.33kPa,心律90次/分,律齐音中,神静气平。继续予葡萄糖酸钙、维生素C等静滴,
Children male, 10 years old. Due to sustained high fever for 1 week on September 4, 1993 for treatment, 1 week to 39 ~ 40 ℃ temperature, night low night, light cough, sore throat, no vomiting. Had in hospital treatment, used penicillin, ampicillin, cephalexin and other heat did not retire. Past history of drug allergy. Physical examination: T39.5 ℃, acute fever tolerance, flatness, throat congestion, tonsil enlargement Ⅱ degree, no secretions, cardiopulmonary auscultation no abnormalities. Laboratory tests: WBC 18 × 10 ~ 9 / L, N0.8, L0.2. Chest thoracic, urine routine are normal. To be diagnosed “fever to be checked.” To ampicillin, cefalotin intravenous infusion. Cefcyclohexene (produced by Hangzhou Minsheng Pharmaceutical Factory, Lot No. 930518) was diluted to 2.5% concentration with 10% glucose solution (manufactured by Zhejiang Xinchang Pharmaceutical Factory, Lot No. 9302102) and dripped for about 2 to 3 minutes at a rate of 30 drops per minute , Children with systemic redness of symmetrical erythema. Immediate non-intramuscular injection needle 25mg, and slow down drip rate. For a moment, the rash increased fusion scarlet fever-like rash, the patient complained of chest tightness, nausea, immediate withdrawal. Physical examination, BP10 / 6kPa, shortness of breath drunk appearance, fear of uneasiness, lips cyanosis, extremity purple cold, pulse weakness, heart rate 120 beats / min, heart sound low blunt, breathing 46 beats / min. Oxygen immediately, intravenous 0.001% epinephrine 3ml, dexamethasone 5ml. Cyanosis about 10 minutes to reduce, BPl2.7 / 9.33kPa, heart rate 90 beats / min, law Qi sound, Shen Jing peace. Continue to calcium gluconate, vitamin C and other intravenous infusion,