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目的:探讨胰高血糖素瘤的临床特点及诊疗方法。方法:回顾分析两例胰高血糖素瘤患者的临床资料及诊疗经过,并结合文献进行分析。结果:两例患者都曾因糖尿病、消瘦、舌炎、坏死松解性游走性红斑等症状就诊于内分泌科及皮肤科,影像学检查提示胰尾占位。两例均行胰体尾及脾脏切除术,术后血糖控制有效,相应伴随症状消失,其中1例患者于术后3年复查CT提示肝脏占位,再次入院行肝右后叶切除、肝左叶肿瘤局部切除及胆囊切除术。结论:胰高血糖素瘤相关临床症状较多,早期诊断较困难,影像学检查对其诊断有一定帮助,外科手术切除仍是其治疗的有效方式。
Objective: To investigate the clinical features and diagnosis and treatment of glucagonoma. Methods: The clinical data, diagnosis and treatment of two cases of glucagonoma were retrospectively analyzed and analyzed according to the literature. Results: Both of the two patients were treated in endocrinology and dermatology due to diabetes mellitus, emaciation, glossitis, necrotizing erythematous erythema, and so on. Image examination revealed that the tail of the tail was occupied. Two cases were performed pancreatic body tail and splenectomy, postoperative blood glucose control effective, the corresponding accompanying symptoms disappear, of which 1 patient 3 years after the CT review prompted liver space occupancy, re-admission after the right hepatic lobe resection, liver left Local lobectomy and cholecystectomy. Conclusion: There are many clinical symptoms related to glucagonoma. Early diagnosis is difficult. Imaging examination may be helpful in the diagnosis. Surgical resection is still an effective way to treat it.