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目的:探讨传统手术与鼻内镜辅助手术治疗嗅神经母细胞瘤的疗效。方法:回顾性分析嗅神经母细胞瘤患者共19例,采用传统手术切除肿瘤(A组)共10例,其中4例经鼻腔切除,6例经鼻侧切开切除;鼻内镜辅助手术(B组)共9例,其中2例在鼻内镜下经鼻腔切除,6例采取鼻侧切开与鼻内镜辅助手术切除,另外1例经颅面联合径路切除。2组患者术后均接受常规放疗。结果:A组和B组患者5年生存率分别为50.0%、88.9%,肿瘤局部复发率分别为50.0%、33.3%,平均复发时间分别为5.2个月和16.0个月;2组5年生存率和肿瘤局部复发率差异无统计学意义,平均复发时间差异有统计学意义。结论:鼻内镜辅助手术治疗嗅神经母细胞瘤,照明好,视野清晰,更易完整彻底地切除肿瘤,延缓复发时间。
Objective: To investigate the efficacy of traditional surgery and endoscopic sinus surgery in the treatment of olfactory neuroblastoma. Methods: A total of 19 patients with olfactory neuroblastoma were retrospectively analyzed. Totally 10 patients underwent conventional surgical resection of the tumor (group A), 4 of whom underwent nasal resection and 6 underwent nasal resection. Endoscopic assisted surgery B group). A total of 9 patients underwent endoscopic sinus surgery, including nasal resection in 2 cases, nasal resection in 6 cases and endoscopic sinus surgery in 1 case. Both groups received conventional radiotherapy after operation. Results: The 5-year survival rates of group A and group B were 50.0% and 88.9% respectively, and the local recurrence rates were 50.0% and 33.3% respectively. The average recurrence time was 5.2 months and 16.0 months respectively. The 5-year survival rates There was no significant difference in rates and local tumor recurrence rates between the two groups. The mean recurrence time was statistically significant. Conclusion: Endoscopic sinus surgery for the treatment of olfactory neuroblastoma, good lighting, clear vision, more complete and complete removal of the tumor, delay the relapse time.