【摘 要】
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The combination between biphasic calcium phosphate (BCP) and the osteomimetic porous micro-structure obtained via freeze casting is hoped to achieve excellent bone regeneration,while the effects of HA and β-TCP ratio changes on the degradation and biologi
【机 构】
：
Department of Stomatology,Third Xiangya Hospital,Central South University,Changsha 410013,China
论文部分内容阅读
The combination between biphasic calcium phosphate (BCP) and the osteomimetic porous micro-structure obtained via freeze casting is hoped to achieve excellent bone regeneration,while the effects of HA and β-TCP ratio changes on the degradation and biological performance of the BCP scaffolds with this unique micro-structure need to be determined.Here,we prepared the osteomimetic BCP scaffolds with different HA/β-TCP ratios (HA30/β-TCP70,HA50/β-TCP50,HA70/β-TCP30)and the effects of different HA/β-TCPHA/β-TCP ratios on the degradation and biological performance were studied in vitro and vivo.These BCP scaffolds with different HA/β-TCP ratios exhibited similar microstructure,mechanical performance,and protein absorption capability,while HA70/β-TCP30 BCP scaffolds showed an advisable degradation rate.Study in vitro confirmed the bio-com-patibility and promotion on the proliferation,differentia-tion of MG63 cells in the porous osteomimetic BCP scaffolds with a HA/β-TCP ratio at 30∶70.Implantation experiments also showed that the porous osteomimetic BCP scaffolds with a HA/β-TCP ratio at 30∶70 had excellent bone regeneration capacity and proper degrada-tion rate compatible with bone growth.These results reveal that the porous osteomimetic BCP scaffold with a HA/β-TCP ratio at 30∶70 is a potential candidate of biodegradable bone substitutes used for bone repair.
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