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Pluronic F-127由70%氧化乙烯和30%氧化丙烯组成,其平均分子量为11500,它是一种性质独特的逆向热凝胶,20～40%水溶液在冰箱温度(4～5℃)下为流体,在室温下成为软凝胶.Pluronic的毒性很低,将它作为溶媒做成的制剂适用于人体皮表或体腔内,可形成固态的人工屏障和药物稳释贮库.本文报道了吲哚美辛Pluronic凝胶的直肠吸收以及对直肠粘膜的作用.
Pluronic F-127 consists of 70% ethylene oxide and 30% propylene oxide and has an average molecular weight of 11,500. It is a unique reverse thermal gel with 20 to 40% water solution at refrigerator temperature (4 to 5 ° C) Fluid, become a soft gel at room temperature.Pluronic low toxicity, made it as a solvent formulation suitable for human skin or body cavity skin can form a solid artificial barrier and drug stable release reservoir.This paper reports the indole Rectal uptake of the tropicin Pluronic gel and its effect on the rectal mucosa.