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目的 观察高聚金葡素对晚期肺癌合并恶性胸腔积液的疗效。方法 32例设为对照组 ,常规全身行EP方案化疗并顺铂胸腔内注射 ;观察组 32例 ,在作上述常规治疗的同时 ,加用肌注和胸腔内注入高聚金葡素。结果 观察组胸水吸收的有效率达 71 9% ,karnofsky评分上升率为78 1%均优于对照组的 4 3 8%和 4 0 6 % (P <0 0 1) ,而白细胞减少和胃肠道反应的发生率均比对照组低 (P <0 0 1)。结论 在全身和胸腔内应用抗癌药治疗晚期肺癌合并恶性胸腔积液的基础上加用高聚金葡素可提高胸水吸收的有效率 ,改善生活质量 ,减少化疗毒副作用
Objective To observe the effect of polyglutamine on advanced lung cancer with malignant pleural effusion. Methods Thirty-two cases were treated with EP regimen and intraperitoneal injection of Cisplatin in 32 patients in the observation group. Conventional systemic chemotherapy and intrapleural injection of polyglutamine were used. Results The effective rate of pleural effusion absorption in observation group was 71 9% and the karnofsky score increased rate was 78 1%, which was better than that of control group (P <0.01), while leukopenia and gastrointestinal The incidence of tract reactions was lower than that of the control group (P <0.01). Conclusion The application of APA in the treatment of advanced lung cancer combined with malignant pleural effusion in systemic and thoracic cavity can improve the efficiency of pleural fluid absorption, improve the quality of life and reduce the side effects of chemotherapy