It is universally acknowledged by network security experts that proactive peer-to-peer (P2P) worms may soon en-gender serious threats to the Internet infrastructures. These latent threats stimulate activities of modeling and analysis of the proactive P2P worm propagation. Based on the classical two-factor model,in this paper,we propose a novel proactive worm propagation model in unstructured P2P networks (called the four-factor model) by considering four factors:(1) network topology,(2) countermeasures taken by Internet service providers (ISPs) and users,(3) configuration diversity of nodes in the P2P network,and (4) attack and defense strategies. Simulations and experiments show that proactive P2P worms can be slowed down by two ways:improvement of the configuration diversity of the P2P network and using powerful rules to reinforce the most connected nodes from being compromised. The four-factor model provides a better description and prediction of the proactive P2P worm propagation. It is universally acknowledged by network security experts that proactive peer-to-peer (P2P) worms may soon en-gender serious threats to the Internet infrastructures. The sun threats activities of modeling and analysis of the proactive P2P worm propagation. Based on the classical two-factor model, in this paper, we propose a novel proactive worm propagation model in unstructured P2P networks (called the four-factor model) by considering four factors: (1) network topology, (2) countermeasures taken by Internet service providers (ISPs) and users, (3) configuration diversity of nodes in the P2P network, and (4) attack and defense strategies. Simulations and experiments show that proactive P2P worms can be slowed down by two ways: improvement of the configuration diversity of the P2P network and using powerful rules to reinforce the most connected nodes from being compromised. The four-factor model provides a better description and prediction of the proactive P2P worm propagation.