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目的:研究诱导型一氧化氮合酶(iNOS)在颌骨肉瘤中的表达情况及其和肿瘤血管形成、临床病理特征之间的关系。方法:应用S-P免疫组织化学法检测iNOS和CD34在颌骨肉瘤中的表达。结果:颌骨肉瘤中存在iNOS的过度表达;iNOS表达与微血管密度有关;iNOS表达与颌骨肉瘤大小、病理分级、临床分期、初/复发等临床病理特征有关,与肿瘤的转移无关。结论:iNOS有促进颌骨肉瘤中肿瘤血管形成的作用,iNOS是肿瘤治疗的一个重要靶点。
Objective: To investigate the expression of inducible nitric oxide synthase (iNOS) in jaw osteosarcoma and its relationship with tumor angiogenesis and clinicopathological features. Methods: The expression of iNOS and CD34 in jaw osteosarcoma was detected by S-P immunohistochemistry. Results: The expression of iNOS was related to the microvessel density in ipsilateral sarcoma. The expression of iNOS was related to the size, pathological grade, clinical stage and initial / recurrence of ipsilateral sarcoma. There was no correlation between iNOS expression and tumor metastasis. Conclusion: iNOS can promote the tumor angiogenesis in jaw osteosarcoma. INOS is an important target of tumor therapy.