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白三烯是花生四烯酸经脂氧化酶等一系列作用生成的一组生物活性物质。近年来研究发现,白三烯与炎症性胃肠疾病有明显关系,炎症性肠病病变粘膜LTB_4,ITC_4明显增加,且是这类疾病的重要炎性介质,白三烯具有强烈趋化及激活作用,能使胃肠平滑肌收缩、血管通透性增加,与胃肠道炎症的发生、发展和严重性呈正比关系。白三烯抑制剂的研究为炎症性疾病的冶疗提供了一种有效的、值得认真探索的、大有前途的新方法。也为进一步研究炎症性胃肠疾病的病因,发病机理提供了方向。
Leukotriene is a group of bioactive substances produced by a series of effects of arachidonic acid and lipoxygenase. In recent years, studies have found that leukotrienes and inflammatory gastrointestinal diseases have a clear relationship between inflammatory bowel disease mucosa LTB_4, ITC_4 significantly increased, and is an important inflammatory mediators of these diseases, leukotrienes with strong chemotaxis and activation Role, can make gastrointestinal smooth muscle contraction, increased vascular permeability, and gastrointestinal inflammation, development and severity were in direct proportion. The study of leukotriene inhibitors has provided an effective, promising and promising new method for the treatment of inflammatory diseases. It also provides a direction for further study of the etiology and pathogenesis of inflammatory gastrointestinal diseases.