肺泡表面活性物质已发现30多年,其数量的减少、缺乏常与某些临床疾病有关,它是基础与临床医学研究的重要课题。早在1929年 Von Nergaard 就发现肺存在表面张力。他用新鲜离体猫肺标本,分别逐步地从气管注入定量的空气和盐水,直至肺容积扩大到很大程度,再将气体和盐水抽出,并记录容积改变与相应的压力变化,绘 Alveolar surfactant has been found for more than 30 years. The decrease of its quantity and deficiency are often associated with some clinical diseases. It is an important issue in basic and clinical medicine research. As early as 1929, Von Nergaard discovered that there is surface tension in the lungs. Using freshly isolated lung specimens of cats, he gradually infused quantitative air and saline respectively from the trachea until the lung volume expanded to a large extent, and then extracted the gas and saline and recorded volume changes and corresponding pressure changes