论文部分内容阅读
目的观察生长抑素施他宁及其类似物善宁治疗重症急性胰腺炎(SAP)的治疗效果及评估其临床价值。方法按Ran son标准判断病情严重程度,将106例病情大致相近的SAP患者分成施他宁治疗组37例,善宁治疗组36例及对照组33例。对照组用一般常规治疗方法,治疗组在一般常规治疗方法治疗的基础上加用施他宁6mg/d或善宁0.6mg/d,维持治疗7～14d。观察3组血尿淀粉酶变化、平均腹痛持续时间、禁食天数、住院天数、并发症、手术率及住院费用等多项指标。结果施他宁和善宁治疗SAP均能显著降低血尿淀粉酶水平,控制腹痛,缩短禁食时间和住院天数,减少并发症和手术率,并且没有明显的增加住院费用。结论生长抑素施他宁和善宁对SAP有明显疗效,可以阻止病情进展和恶化,减少并发症,改善预后。
Objective To observe the effect and clinical value of somatostatin and its analogue Shanning in the treatment of severe acute pancreatitis (SAP). Methods According to Ran son standard to determine the severity of the disease, 106 cases of approximately similar SAP patients were divided into stratanin treatment group 37 cases, Shanning treatment group 36 cases and control group 33 cases. The control group with the conventional treatment, the treatment group based on the general treatment of conventional therapy plus the use of Shitonin 6mg / d or Shanning 0.6mg / d, maintenance treatment 7 ~ 14d. The changes of blood urea amylase, average duration of abdominal pain, fasting days, days of hospitalization, complications, operation rate and hospitalization costs were observed in three groups. Results Sitatin and Shannon treatment of SAP can significantly reduce the level of serum amylase, control abdominal pain, shorten the fasting and hospitalization days, reduce complications and surgical rates, and no significant increase in hospital costs. Conclusion Somatostatin and strychnine have obvious curative effect on SAP, which can prevent the progression of the disease and the deterioration, reduce the complication and improve the prognosis.