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代谢组学主要是通过分析生物体受到外界刺激后产生的相对分子质量低的内源性代谢产物来推断生物体的生理病理状态。代谢组学研究的整体、动态特点与中医药的整体和辩证论治特点相吻合,代谢组学已应用于中药现代化研究,推动了中医药的发展。本文查阅国内外有关代谢组学在单味中药及中药复方中的药效以及毒性方面研究的文献,总结了代谢组学在中药现代化研究中的成果,为该方面的研究提供参考。
Metabolomics mainly infers the physiological and pathological states of organisms by analyzing endogenous metabolites of low molecular weight produced by organisms after external stimulation. The overall and dynamic characteristics of metabolomics research are consistent with the overall and dialectical treatment characteristics of traditional Chinese medicine. Metabolomics has been applied to the modernization of traditional Chinese medicine and promoted the development of traditional Chinese medicine. This article reviews the domestic and foreign literatures on the efficacy and toxicity of metabonomics in single herb and Chinese herbal compound, summarizes the results of metabolomics research in the modernization of traditional Chinese medicine, and provides reference for this research.