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目的 探讨人类免疫缺陷病毒 (HIV)感染者结核菌素试验反应状况及与免疫系统的受损程度的联系。方法 采取前瞻性病例对照研究方法 ,同时在病例和对照间做结核菌素试验 ,并对HIV抗体阳性的病例进行细胞免疫水平的测定 ,采用的指标有 :CD4、CD8计数及CD4 CD8比值等 ,观察反应情况。结果 5 5例人类免疫缺陷病毒感染者 (HIV + )结核菌素PPD阳性反应率 (9.8% ) ,远比对照组 (2 8.2 % )低得多 (P <0 .0 1) ,反应情况与患者的细胞免疫受损程度尚待研究 ,但当CD4细胞计数 <2 0 0 (艾滋病患者 )时 ,PPD均无反应 (0× 0 ) ,当CD4细胞计数 >30 0时有部分强阳性反应 (>15mm)。结论 人类免疫缺陷病毒感染者 (HIV + )结核菌素PPD阳性反应率较常人低得多 (P <0 .0 1) ,其PPD无反应问题尚待解决。
Objective To investigate the reaction status of tuberculin test in patients infected with human immunodeficiency virus (HIV) and its relationship with immune system damage. Methods A prospective case-control study was conducted. At the same time, tuberculin test was performed between the cases and controls. The cellular immune levels of HIV-positive cases were determined. The indicators used included CD4, CD8 count and CD4 CD8 ratio, Observe the reaction. Results The positive rate of tuberculin PPD in 5 5 human immunodeficiency virus-infected persons (HIV +) was much lower (9.8%) than in the control group (8.2%) (P <0.01) The extent of cellular immune damage is yet to be studied, but no PPD response (0 × 0) was observed at CD4 counts <200 (AIDS patients), with some strongly positive responses at CD4 cell counts> 300 > 15mm). Conclusions The positive rate of tuberculin PPD in human immunodeficiency virus-infected (HIV +) patients is much lower than that of ordinary people (P <0.01). The problem of PPD non-response remains to be solved.