一、转移因子的发现与进展1949年Lawreace在研究人结核菌素过敏反应时,首先发现将对结核菌素反应阳性的病人(Donor供体)的活白细胞,皮下注射于对结核菌素反应阴性的人(Recipient受体)身上后,受体便迅速出现阳性结核菌素皮试反应,这说明白细胞能转移结核菌素过敏反应。1954～1955年,Lawrence等进一步将阳性病人的白细胞分离出来,再用机械方法或用反复冻融的方法使白细胞破裂,这种白细胞提取物仍然具有转移迟发型变态反应的作用,说明是白细胞中的某些成份在起作用。这种与转移迟发型变态反应有关的成分即称 First, the discovery and progress of transfer factor In 1949, Lawreace in the study of tuberculin allergic reaction, first found in tuberculin-positive patients (Donor donor) live white blood cells, subcutaneous injection of tuberculin-negative (Recipient receptor) body, the receptor will soon appear positive tuberculin skin test reaction, indicating that white blood cells can transfer tuberculin allergic reactions. From 1954 to 1955, Lawrence et al further separated leukocytes from positive patients and then ruptured leukocytes mechanically or by repeated freeze-thaw cycles. This leukocyte extract still has the function of delayed metastatic allergic reaction, indicating that leukocytes Some of the ingredients at work. This transfer of delayed-type allergic reaction-related ingredients that is called