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目的观察脑心通胶囊对急性缺血性脑卒中恢复期运动功能和D-二聚体、血小板聚集率的影响。方法选择本院神经内科2012年5月—2016年5月的急性缺血性脑卒中患者90例,随机分为对照组和治疗组各45例,对照组采用基础治疗,治疗组在对照组的基础上加服脑心通胶囊。治疗前后采用美国国立卫生研究院卒中量表(National institute of health stroke scale,NIHSS)和Barthel指数进行评价,并检测血液中D-二聚体和血小板聚集率(platelet aggregation rate,PAg T)。计量资料比较采用t检验,计数资料比较采用χ~2检验,P<0.05为差异有统计学意义。结果对照组患者的总有效率为73.33%,治疗组为91.11%,比较差异有统计学意义(P<0.05)。治疗后治疗组NIHSS评分低于对照组[(3.5±0.6)、(5.7±0.8)分],Barthel指数高于对照组[(88.3±7.1)、(71.6±6.3)分],D-二聚体及PAg T[(0.35±0.06)μg/人、(41.2%±5.7%)分]均显著低于对照组[(0.57±0.08)μg/人、(59.7±4.6)分],差异均有统计学意义(均P<0.05)。结论脑心通胶囊有助于急性缺血性脑卒中恢复期患者运动功能的恢复,并可以有效改善患者血液黏、浓、凝、聚的状态,临床效果较好。
Objective To observe the effect of Naoxintong capsule on motor function, D-dimer and platelet aggregation rate in recovery of acute ischemic stroke. Methods Ninety patients with acute ischemic stroke in our department of neurology from May 2012 to May 2016 were randomly divided into control group and treatment group (n = 45). The control group was treated with basic therapy. The treatment group in the control group On the basis of serving brain Capsule. Before and after treatment, the NIH Stroke Scale (NIHSS) and Barthel Index were used for evaluation, and blood D-dimer and platelet aggregation rate (PAg T) were measured. Measurement data were compared using t test, count data were compared using χ ~ 2 test, P <0.05 for the difference was statistically significant. Results The total effective rate was 73.33% in the control group and 91.11% in the treatment group, the difference was statistically significant (P <0.05). The NIHSS score of the treatment group was lower than that of the control group [(3.5 ± 0.6), (5.7 ± 0.8)], Barthel index was higher than that of the control group [(88.3 ± 7.1), (71.6 ± 6.3) Body weight and PAg T [(0.35 ± 0.06) μg / person, (41.2% ± 5.7%)] were significantly lower than those in the control group [(0.57 ± 0.08) μg / person, (59.7 ± 4.6) Statistical significance (all P <0.05). CONCLUSION Naoxintong capsule can help the recovery of motor function in patients with acute ischemic stroke and can effectively improve the state of blood viscosity, concentration, coagulation and aggregation in patients with acute ischemic stroke. The clinical effect is better.