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弥散性血管内凝血(DIC)是一种获得性出血综合征,发生在许多疾病的病理过程中。研究发现多种细胞团子释放、生理抗凝因子缺乏及纤维蛋白溶解受抑制等在DIC发病机制中起重要作用。一些新的实验室检查项目以及较敏感或特异指标的测定对DIC的诊断提供了更加可靠的依据。随着对该病发病机制的认识,抗凝血酶Ⅲ蛋白C浓缩剂、组织因子抑制剂等新药不断产生,并在临床试用,有些取得了良好的效果。
Disseminated intravascular coagulation (DIC) is an acquired hemorrhagic syndrome that occurs in the pathology of many diseases. The study found that a variety of cell lumps release, lack of physiological anticoagulation factor and inhibition of fibrinolysis play an important role in the pathogenesis of DIC. Some new laboratory tests and more sensitive or specific indicators of the diagnosis of DIC provides a more reliable basis. With the understanding of the pathogenesis of the disease, antithrombin Ⅲ protein C concentrates, tissue factor inhibitors and other new drugs continue to produce, and in clinical trials, and some have achieved good results.