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目的:观察美托洛尔联合硝苯地平缓释片治疗高血压的临床疗效。方法:将180例高血压患者随机分为对照组1组、对照组2组和治疗组,每组60例。对照1、2组分别口服美托洛尔和硝苯地平缓释片,治疗组给予口服硝苯地平缓释片和美托洛尔,3组疗程均为8周。测定治疗前后3组患者的血压、心率等的变化,记录不良反应。结果:3组治疗前后收缩压和舒张压下降自身比较差异均有统计学意义(P<0.05,P<0.01),且治疗组下降更明显;对照1组和对照2组患者均出现心律波动,治疗组心率较为稳定。结论:采用美托洛尔联合硝苯地平缓释片治疗高血压临床疗效明显,且不良反应少,优于单纯使用硝苯地平缓释片。
Objective: To observe the clinical efficacy of metoprolol combined with nifedipine sustained-release tablets in the treatment of hypertension. Methods: One hundred and eighty hypertensive patients were randomly divided into control group (1), control group (2) and treatment group (60 cases). The control groups 1 and 2 were orally given metoprolol and nifedipine sustained-release tablets, the treatment group were given oral nifedipine sustained-release tablets and metoprolol, the three groups were treated for 8 weeks. Before and after treatment, the changes of blood pressure, heart rate and other three groups were measured and adverse reactions were recorded. Results: Before and after treatment, systolic blood pressure and diastolic blood pressure decreased significantly (P <0.05, P <0.01), and the treatment group decreased more obviously. The control group 1 and control group 2 patients had heart rhythm fluctuations, The treatment group heart rate is more stable. Conclusion: Metoprolol combined with nifedipine sustained-release tablets in the treatment of hypertension clinical efficacy, and adverse reactions less than the simple use of nifedipine sustained-release tablets.