信号调节蛋白(SIRPs)是免疫球蛋白超家族的成员,一种具有抑制作用的跨膜糖蛋白。SIRPs在细胞与细胞的接触、细胞与细胞外基质的接触中发挥信号转导的作用,它对白细胞、神经细胞和各种癌症细胞的功能都有重要的影响,尤其在肿瘤中可能作为一种抑癌蛋白发挥作用。SIRPs可抑制癌细胞的增殖、迁移、侵袭,促进凋亡,从而发挥抑制癌症发展的作用。因此,SIRPs将成为一种新的肿瘤生物学标志物和治疗靶点。 Signal Regulatory Proteins (SIRPs) are members of the immunoglobulin superfamily, an inhibitory transmembrane glycoprotein. SIRPs play a role in signal transduction between cell-cell contact and cell-extracellular matrix contact and have a significant effect on the function of leukocytes, neurons and various cancer cells, especially in tumors Suppressor protein play a role. SIRPs can inhibit the proliferation, migration, invasion and apoptosis of cancer cells, which can inhibit the development of cancer. Therefore, SIRPs will become a new tumor biomarker and therapeutic target.