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为观察胰岛素样生长因子１受体基因在动脉粥样硬化组织中的表达及分布，建立实验性动脉粥样硬化家兔模型。采用人胰岛素样生长因子１受体ｃＲＮＡ探针进行组织原位杂交。结果发现，正常对照的家兔主动脉组织，仅在外膜显示有胰岛素样生长因子１受体ｍＲＮＡ的阳性表达，中膜及内膜均呈阴性；实验组主动脉的整个血管壁，包括外膜、中膜、新生内膜及动脉粥样硬化斑块组织均有胰岛素样生长因子１受体基因的表达。研究提示，增殖的血管平滑肌细胞、新生的内皮细胞及构成动脉粥样硬化斑块主要成分的泡沫细胞均为胰岛素样生长因子１受体ｍＲＮＡ表达的靶细胞，证实胰岛素样生长因子１受体基因参与动脉粥样硬化的发生。
In order to observe the expression and distribution of insulin-like growth factor-1 receptor gene in atherosclerotic tissues, an experimental atherosclerotic rabbit model was established. Human insulin-like growth factor 1 receptor cRNA probe for tissue in situ hybridization. The results showed that the normal control rabbit aortic tissue, only in the outer membrane showed insulin-like growth factor 1 receptor mRNA expression was negative, the media and the intima were negative; experimental aorta throughout the vessel wall, including the outer Membrane, in the membrane, neointimal and atherosclerotic plaque tissue insulin-like growth factor 1 receptor gene expression. Studies suggest that proliferation of vascular smooth muscle cells, endothelial cells and the formation of atherosclerotic plaques constitute the main component of the foam cells are insulin-like growth factor 1 receptor mRNA target cells confirmed that insulin-like growth factor 1 by Somatic genes involved in the development of atherosclerosis.