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作者对1969年到1993年诊治的49例年龄大于60岁的急性淋巴细胞白血病(ALL)患者进行了回顾性研究。这些患者发病之初的生物学特征、中位白细胞数、FAB分型、免疫表型等与成人ALL组没有区别。 按治疗方案的不同将患者分为A、B两组。A组(13例),给予长春新碱(VCR)、柔红霉素(DNR)、门冬酰胺酶(L-ASP)、泼尼松(PDN)。B组(36例)给予常规的VCR、PDN二药温和诱导,其中有4例应用了L-ASP。 49倒患者中,16例接受了中枢神经系统白血病(CNSL)预防治疗;10例单用氨甲喋呤(MTX)鞘注,2例鞘注MTX及全身应用MTX 1g/m~2,2例鞘注
The authors retrospectively studied 49 patients with acute lymphoblastic leukemia (ALL) older than 60 years who were diagnosed and treated from 1969 to 1993. The initial biological characteristics, median leukocyte count, FAB type, and immunophenotype in these patients did not differ from those in the adult ALL group. Patients were divided into A and B groups according to different treatment options. In group A (13 cases), vincristine (VCR), daunorubicin (DNR), asparaginase (L-ASP), and prednisone (PDN) were administered. In group B (36 cases), mild induction of conventional VCR and PDN was given, and 4 of them were treated with L-ASP. Of the 49 patients, 16 patients received CNSL prophylaxis; 10 patients received MTX alone, 2 patients received MTX sheath and MTX 1g/m2, and 2 patients received sheath injection.