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人绒膜促性腺激素(hCG)是一种妊娠激素,其化学的、生物的特性类似垂体的黄体生成素(LH)。在妊娠早期,hCG主要是维持黄体的生长活动。它是一种二聚分子,约有35％糖与α和β亚单位共价连接。有关hCG的多肽和糖两部分的分子结构都已了解清楚。 hCG与细胞膜受体接合后激活腺嘌呤环化酶,使环腺苷酸(cAMP)上升,从而产生一系列的细胞内部变化,以后发生激素反应。这些糖蛋白的独特糖部分的确切作用仍不完全清楚。通过连续的酶分解作用或一次化学
Human chorionic gonadotropin (hCG) is a pregnancy hormone that is chemically and biologically similar to pituitary luteinizing hormone (LH). In early pregnancy, hCG is mainly to maintain the growth of luteal activity. It is a dimeric molecule and about 35% of the sugar is covalently attached to the alpha and beta subunits. The molecular structure of both the polypeptide and the sugar of hCG is well understood. After hCG binds to the cell membrane receptor, adenine cyclase is activated, causing cAMP to rise, resulting in a series of intracellular changes that are followed by a hormone response. The exact role of the unique sugar moiety of these glycoproteins is still not fully understood. Through continuous enzymatic cleavage or once chemistry