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1993年10月~1997年1月,用EMA/CO方案联合化疗治疗妊娠恶性滋养细胞肿瘤(GTT)26例,总结其疗效和毒副作用。在可评价疗效的22例中,近期治愈21例,治愈率95.5%,恶性葡萄胎(恶葡)治愈率100%,绒癌治愈率90.0%。生存期2~39个月,中位生存期16个月。本组毒副作用主要为胃肠道反应、脱发及白细胞下降,毒性范围多在Ⅰ~Ⅱ度,均可耐受,停药后即可恢复正常。作者认为:EMA/CO方案疗效高,见效快,毒性小,可用于治疗各期滋养细胞肿瘤,尤其适用于重症及耐药患者。
From October 1993 to January 1997, 26 cases of pregnancy-induced gestational trophoblastic tumor (GTT) were treated with EMA / CO regimen combined with chemotherapy, and the curative effect and side effects were summarized. Among the 22 evaluable curative effects, 21 cases were cured in the near future, with a cure rate of 95.5%. The cure rate of malignant mole (ECP) was 100% and the cure rate of choriocarcinoma was 90.0%. Survival of 2 to 39 months, the median survival of 16 months. The main side effects of this group of gastrointestinal reactions, hair loss and leukopenia, toxicity in the range of Ⅰ ~ Ⅱ degrees, can be tolerated, to resume normal after withdrawal. The authors believe: EMA / CO program efficacy, quick, low toxicity, can be used to treat various stages of trophoblastic tumors, especially for patients with severe and resistant.