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目的：探讨消心痛注射液治疗急性心肌梗塞（ＡＭＩ）的剂量与疗效的关系。方法：对已确诊的ＡＭＩ患者４５例随机分为３组，分别用消心痛（Ｉｓｏｋｅｔ）２０、４０、６０ｍｇ／ｄ静脉间歇（每天间歇６～８ｈ的无药期）或持续（２４ｈ持续）滴注５～７ｄ，观察患者临床症状的改善情况，心电图变化、血清酶学的改变及死亡率。结果：疗效与上述药物剂量及用药方式（间歇或持续）无显著相关性（Ｐ＞００５）。结论：为了预防硝酸酯类的耐药性及病人依赖性的发生，同时节省药费开支，以２０～４０ｍｇ／ｄ且间歇静滴为宜。
Objective: To investigate the relationship between the dosage and the curative effect of XiaoXiaoPong injection on acute myocardial infarction (AMI). Methods: Forty-five patients with diagnosed AMI were randomly divided into 3 groups: Isoket 20, 40 and 60 mg / d intravenously (intermittent 6-8h intermittently) or continuous (24h continuous) Note 5 ~ 7d, to observe the improvement of clinical symptoms, ECG changes, changes in serum enzymes and mortality. Results: There was no significant correlation between the curative effect and the dosage of the above drugs and the mode of administration (intermittent or continuous) (P> 005). Conclusion: In order to prevent the nitrate resistance and patient dependence, while saving medical expenses, with 20 ~ 40mg / d and intermittent intravenous infusion is appropriate.