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目的探讨nueropilin-1(NRP-1)在乳腺浸润性导管癌中的表达及其与临床病理特征的相关性。方法应用免疫组化EnVision法检测50例乳腺浸润性导管癌(包括有腋淋巴结转移22例及无腋淋巴结转移28例)及30例乳腺良性疾病组织中NRP-1的表达,分析其表达与患者临床病理特征之间的关系。结果乳腺癌组织中NRP-1阳性表达率明显高于乳腺纤维腺瘤和乳腺囊性增生症(P<0.05),乳腺浸润性导管癌患者中,NRP-1的表达强度与腋窝淋巴结转移和TNM分期密切相关(P<0.01)。结论 NRP-1过度表达可能参与了乳腺癌发生淋巴结转移的过程。
Objective To investigate the expression of nueropilin-1 (NRP-1) in invasive ductal carcinoma of breast and its relationship with clinicopathological features. Methods The expression of NRP-1 in 50 cases of breast invasive ductal carcinoma (including 22 cases of axillary lymph node metastasis and 28 cases of non-axillary lymph node metastasis) and 30 cases of benign breast diseases were detected by EnVision immunohistochemistry. The expression of NRP- The relationship between clinicopathological features. Results The positive expression rate of NRP-1 in breast cancer tissues was significantly higher than that in breast fibroadenoma and cystic hyperplasia (P <0.05). The expression of NRP-1 in breast invasive ductal carcinoma patients was significantly correlated with axillary lymph node metastasis and TNM Staging is closely related (P <0.01). Conclusion NRP-1 overexpression may be involved in the process of lymph node metastasis in breast cancer.