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【目的】探讨益气活血片对人工寒潮促发脑卒中大鼠凝血和纤溶系统的影响。【方法】选用SD大鼠,随机分为4组,按照双肾双夹法复制易卒中型肾血管性高血压大鼠模型,中药组给予益气活血片(剂量为1.89 g·kg-1·d-1),阳性对照组给予阿司匹林(剂量为80 mg·kg-1·d-1),模型组及空白对照组给予等容积蒸馏水,从高血压模型复制术后14 d开始,每天1次,直到112 d后置于人工寒潮箱中3 d诱发卒中,取血检测血浆凝血酶激活的纤溶抑制物(TAFI)、蛋白C(PC)、凝血酶—抗凝血酶复合物(TAT)及纤溶酶(PAP)水平。【结果】与模型组比较,益气活血片组可显著降低血浆TAFI、PC、TAT、PAP水平,差异均有统计学意义(P<0.05)。【结论】益气活血片对脑卒中的防治作用与其能改善凝血和纤溶系统的平衡状态有关。
【Objective】 To investigate the effect of Yiqi Huoxue Tablet on blood coagulation and fibrinolytic system in stroke-induced stroke in rats. 【Methods】 SD rats were randomly divided into 4 groups. The rat model of renal hypertension induced by stroke was duplicated according to the double-kidney double clamp method. The TCM group was given Yiqi Huoxue Tablet (dose of 1.89 g · kg-1 · d-1). Aspirin was given to the positive control group (80 mg · kg-1 · d-1) at a dose of 80 mg · kg-1 · d-1. The model group and the blank control group were given isotonic distilled water. , Which were induced to stroke for 3 days in artificial cold box after 112 days. Blood samples were collected for determination of plasma thrombin-activated fibrinolysis inhibitor (TAFI), protein C (PC), thrombin-antithrombin complex (TAT) And plasmin (PAP) levels. 【Results】 Compared with model group, Yiqihuoxue Tablet group could significantly reduce plasma TAFI, PC, TAT, PAP levels, the differences were statistically significant (P <0.05). 【Conclusion】 The preventive and therapeutic effects of Yiqi Huoxue Tablets on stroke are related to its ability to improve the balance of coagulation and fibrinolysis systems.