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目的:研究血清抵抗素(SR)水平与2型糖尿病(T2DM)合并高血压患者血压的相关性。方法:选择T2DM合并高血压患者(T2DM合并高血压组)124例,单纯T2DM患者(单纯糖尿病组)85例,正常对象(正常对照组)71例纳入研究。根据血压水平,T2DM合并高血压组被进一步分为1级亚组(34例),2级亚组(43例)和3级亚组(47例)。取外周静脉血测量三组SR及其他指标水平。Logistic多元回归分析用来分析影响血压水平的危险因素。Kendall′s tau-b相关分析用来分析SR,空腹胰岛素,量化胰岛素敏感指数和胰岛素抵抗指数与血压水平的相关性。结果:与健康对照组比较,单纯糖尿病组和T2DM合并高血压组SR水平显著升高[(7.21±2.65)ng/ml比(19.87±3.67)ng/ml比(31.32±3.89)ng/ml],且T2DM合并高血压组的显著高于单纯糖尿病组的(P均<0.01)。Logistic多元回归分析表明SR水平是影响患者血压水平的独立危险因素(R2=0.087,P<0.05)。Kendall′s tau-b相关分析显示SR水平与高血压患者血压水平呈显著正相关(r=0.202,P=0.001);控制其余影响因素后,二者间仍然呈显著正相关(r=0.233,P=0.022)。结论:血清抵抗素水平是2型糖尿病合并高血压患者的危险因素,与其血压水平呈显著正相关。
Objective: To investigate the relationship between serum resistin (SR) level and blood pressure in type 2 diabetes mellitus (T2DM) patients with hypertension. Methods: One hundred and twenty-four patients with T2DM complicated with hypertension (T2DM with hypertension group), 85 patients with T2DM (simple diabetic group) and 71 normal subjects (normal control group) were enrolled in the study. According to the blood pressure level, the T2DM patients with hypertension group were further divided into one subgroup (34 cases), two subgroups (43 cases) and three subgroups (47 cases). Take peripheral venous blood to measure the three groups of SR and other indicators. Logistic multiple regression analysis was used to analyze the risk factors that affect blood pressure levels. Kendall’s tau-b correlation analysis was used to analyze the association of SR, fasting insulin, quantified insulin sensitivity index, and insulin resistance index with blood pressure levels. Results: Compared with the healthy control group, the level of SR in the patients with T2DM and T2DM complicated with hypertension was significantly higher than that in the healthy controls [(7.21 ± 2.65) ng / ml vs (19.87 ± 3.67) ng / ml vs (31.32 ± 3.89) ng / ml] , And T2DM with hypertension group was significantly higher than simple diabetic group (P <0.01). Logistic multivariate regression analysis showed that SR level was an independent risk factor influencing patients’ blood pressure (R2 = 0.087, P <0.05). Kendall’s tau-b correlation analysis showed that the level of SR was significantly and positively correlated with the blood pressure in hypertensive patients (r = 0.202, P = 0.001). After controlling for the remaining factors, there was still a significant positive correlation (r = 0.233, P = 0.022). Conclusion: Serum resistin level is a risk factor for type 2 diabetes mellitus patients with hypertension, which is positively correlated with its blood pressure level.