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作者应用体外培养和透射电镜技术探讨了人参皂甙抗石棉尘的细胞毒作用。结果表明:加入人参皂甙的石棉组较单纯石棉组在存活率、吞噬功能上有所提高,培养上清中LDH、ACP和MDA产生量减少,超微结构损伤减轻。本实验为石棉肺的预防性给药及石棉的脂质过氧化机理研究提供了参考。
The authors applied in vitro culture and transmission electron microscopy to investigate the cytotoxicity of ginsenosides against asbestos dust. The results showed that the survival rate and phagocytic function of the asbestos group added with ginsenoside were higher than that of the asbestos group. The production of LDH, ACP and MDA in the culture supernatant was reduced, and ultrastructural damage was reduced. This experiment provides a reference for the preventive administration of asbestos lung and the study of lipid peroxidation mechanism of asbestos.