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脂质代谢异常症,是指血浆胆固醇、甘油三酯等血浆脂质成分的异常高值或低值,以及在组织中各种脂质的贮留,如黄色瘤等。调节脂质代谢的脱辅基蛋白、脂蛋白受体和酶的研究已有较大进展,对于由它们的缺陷和功能异常所引起的脂质代谢异常的病态也有了深入的认识。本文仅就脂质代谢异常的最新进展加以叙述。一胆固醇代谢异常1.脂蛋白代谢与胆固醇关于与来源于饮食的外源性胆固醇和体内合成的内源性胆固醇的代谢调节有关的重要因子脱辅基蛋白B(ApoB)的多样性以及脂蛋白受
Abnormal lipid metabolism refers to abnormally high or low plasma lipid components such as plasma cholesterol, triglycerides, and the retention of various lipids in tissues such as xanthoma. Advances in the study of apolipoproteins, lipoprotein receptors, and enzymes that regulate lipid metabolism have progressed, and insights into the pathology of dyslipidemias caused by their defects and dysfunctions have also been made. This article describes only the latest advances in lipid metabolism disorders. Cholesterol Metabolism Abnormalities 1. Lipoprotein Metabolism and Cholesterol Regarding the diversity of apoprotein B (ApoB), an important factor involved in the metabolic regulation of exogenous cholesterol derived from the diet and endogenous cholesterol synthesized in vivo, By