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目的观察苦参素胶囊对低病毒载量慢性乙型肝炎患者肝功能的影响。方法将61例低病毒载量慢性乙型肝炎患者随机分为两组;对照组30例口服甘草酸单钾盐片,治疗组31例口服甘草酸单钾盐片和苦参素胶囊,疗程3个月。结果治疗后两组患者肝功能指标ALT、AST、γ-GGT均有不同程度降低(P<0.05,P<0.01);且治疗组低于对照组(P<0.05)。治疗后治疗组HBV-DNA含量明显降低(P<0.05),且明显低于对照组(P<0.05)。结论苦参素胶囊可改善低病毒载量慢性乙型肝炎患者肝功能,抑制病毒复制。
Objective To observe the effect of matrine capsule on liver function in patients with chronic hepatitis B virus infection. Methods Sixty-one patients with chronic hepatitis B with low viral load were randomly divided into two groups. In the control group, 30 patients were given glycyrrhizin monosodium salt tablets. The treatment group received oral administration of glycyrrhizic acid monopotassium salt tablets and oxymatrine capsules. Treatment 3 Months. Results After treatment, the indexes of ALT, AST and γ-GGT were lower in both groups (P <0.05, P <0.01). The treatment group was lower than the control group (P <0.05). After treatment, the content of HBV-DNA in the treatment group was significantly lower (P <0.05) and significantly lower than that in the control group (P <0.05). Conclusion Oxymatrine capsule can improve liver function and inhibit virus replication in patients with chronic hepatitis B virus infection.