本研究以9例原发性高血压伴肾功能不良的患者为对象,观察了口服心痛定后血浆血管紧张素Ⅱ水平的变化趋势以及在心痛定作用下,患者尿量、尿钠及内生肌酐清除率的变化。我们发现:本组病人服用心痛定后血浆血管紧张素Ⅱ(PATⅡ)水平下降,患者尿量(u.v)、尿钠(uNa)增加,内生肌酐清除率(C.Cr)升高。研究结果表示:口服心痛定对原发性高血压伴肾功能不良的病人,无交感神经兴奋及血管紧张素Ⅱ水平升高的作用,由于肾血流量的增加,患者肾功能亦得到改善。 In this study, 9 patients with essential hypertension with renal dysfunction were studied. The changes of plasma angiotensin Ⅱ level after oral administration of nifedipine and the effect of nifedipine on urine output, urinary sodium and endogenous Changes in creatinine clearance. We found that the patient’s blood pressure after taking angiotensin Ⅱ (PAT Ⅱ) decreased the level of urine volume (u.v), urinary sodium (uNa), endogenous creatinine clearance (C.Cr) increased. The results showed that: oral heartache for patients with essential hypertension with renal dysfunction, no sympathetic nerve stimulation and elevated levels of angiotensin Ⅱ, due to increased renal blood flow, renal function also improved.