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目的 观察基底外侧杏仁核 (BLA)内注射戊巴比妥钠对睡眠和行为的影响。方法 多导睡眠描记术和杏仁核微量注射。结果 戊巴比妥钠引起觉醒减少 ,慢波睡眠和总睡眠时间增多 ,开野实验中踩格数和修饰行为减少 ,而强迫游泳实验的不动时间延长。结论 戊巴比妥钠作用于BLA可产生明显的促睡眠效应和镇静作用 ,BLA参与了睡眠和行为的调节
Objective To observe the effects of sodium pentobarbital injection on the sleep and behavior in the basolateral amygdala (BLA). Methods Polysomnography and amygdala microinjection were performed. Results Sodium pentobarbital caused a decrease of awakening, slow wave sleep and total sleep time. The opening grid number and grooming behavior decreased in open field experiment, but the immobility time of forced swimming experiment was prolonged. Conclusion Sodium pentobarbital can induce sleep deprivation and sedation in BLA, and BLA is involved in the regulation of sleep and behavior