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氯喹在临床上普遍用于抗疟,并可以治疗阿米巴肝脓肿、红斑性狼疮等自身免疫性疾病。近年来由氯喹所引起的不良反应似有增多,现报告我们所见三例由氯喹引起的心源性脑缺血综合征如下。例一王×,女,21岁,因发热二月余于1966年3月31日入院,经检查拟诊为肝脓疡合并败血症,给予氯喹每次0.25克,每日三次。共服2.25克后,觉心里难受,后突然双手抽搐,脸苍白,昏厥,心跳呼吸停止,眼上翻,唇紫绀。立即行胸外心脏挤压,人工呼吸,呼吸心跳相继恢复。心电图示T波低平,Q-T间期延长。此后在6小时内反复发作七次,多次抢救,都经心脏挤压,心腔内注射异丙肾上腺素、吸氧、纠正酸中毒及给予阿托品静滴等措施才脱险。本例病前无癫痫史。例二居×、女、74岁,因隔日畏寒发热,血检查有疟原虫而于1972年10月19日中午即服氯喹0.5克,
Chloroquine is widely used clinically for anti-malaria and can treat autoimmune diseases such as amoebic liver abscess and lupus erythematosus. Adverse reactions caused by chloroquine in recent years seem to increase, we now report three cases of chloride-induced cardiogenic cerebral ischemic syndrome are as follows. A case of a king ×, female, 21 years old, due to febrile February more than March 31, 1966 admission, diagnosed as liver abscess with sepsis, given chloroquine every 0.25 grams, three times a day. After serving a total of 2.25 grams, feel heart uncomfortable, suddenly both hands after convulsions, pale face, fainting, heartbeat stopped, eyes turned, lips cyanosis. Immediate chest compression of the heart, artificial respiration, respiration and heartbeat have been restored. ECG T wave low level, Q-T interval prolongation. After six hours of repeated seizures in seven hours, multiple rescues, all by the heart squeeze, intracardiac injection of isoproterenol, oxygen, correct acidosis and intravenous infusion of atropine and other measures before danger. This case without epilepsy history. Example II Habitat ×, female, 74 years old, chills and fever due to the next day, the blood was checked for Plasmodium and on October 19, 1972 noon clothed chloroquine 0.5 grams,