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目的:研究中国人群血管生成素相关蛋白(ANGPTL3)基因单核苷酸多态性与冠心病的关系。方法:采用聚合酶链反应和限制性酶切的片段长度多态分析方法检测冠心病患者389例,健康人503例的AN-GPTL3基因+90782C/G多态性并统计各组的多态性频率。结果:冠心病亚组与对照组、冠心病心肌梗死组与对照组之间的基因型频率分布差异有统计学意义,C等位基因频率在冠心病组、冠心病心肌梗死亚组和对照组分别为49.6%、51.5%和41.6%(P<0.05)。结论:ANGPTL3基因rs1168013位点C/G多态性与中国人冠心病心肌梗死发病相关,ANGPTL3可能是冠心病发病的易感基因。
Objective: To study the association between single nucleotide polymorphisms of angiopoietin-related protein (ANGPTL3) gene and coronary heart disease in Chinese population. Methods: ANGPTL3 gene + 90782C / G polymorphism in 389 coronary heart disease patients and 503 healthy individuals were detected by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). The polymorphism frequency. Results: There was significant difference in genotype frequencies between CHD subgroup and control group, CHD group and control group, C allele frequency in CHD group, CHD subgroup and control group 49.6%, 51.5% and 41.6% respectively (P <0.05). Conclusion: ANGPTL3 rs1168013 locus C / G polymorphism is associated with the onset of coronary heart disease in Chinese, and ANGPTL3 may be the predisposing gene of coronary heart disease.