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Colorectal cancer is one of the common malignant tumors in China. It poses a serious threat to the national health of China. For advanced colorectal cancer, the main goal of treatment is to prolong survival and improve quality of life. It complements other advantages, showing good therapeutic results. However, how to grasp the timing of integrated Chinese and West Medicine for the treatment of advanced colorectal cancer and use the integrated Chinese and West Medicine treatment methods flexibly contains profound therapeutic art. Prof. YANG Yu-fei is an authoritative expert in the field of integrated Chinese and West medicine for colorectal cancer. She is good at accurately grasping the timing of treatment of integrated Chinese and West Medicine, and flexibly adjusts the treatment strategy according to the specific conditions. In this paper, we shared Professor YANG Yu-feis strategy for treating advanced colorectal cancer with emphasis on integrated Chinese and West Medicine and attached a typical case, with a view to provide reference for the treatment of advanced colorectal cancer with integrated Chinese and West Medicine.