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虽以往许多对照试验显示甲氰咪胍是治疗溃疡高度有效的药物,但是治愈后相隔几周或几个月,溃疡复发率竟达70～90％。作者等对甲氰咪胍治愈的病人继续用甲氰咪胍或者用生胃酮维持治疗,以比较二药的效果。门诊十二指肠溃疡患者共60例,年龄为19～58岁。应用甲氰咪胍1g/天,连续服用4或6周后,经内窥镜检查证实溃疡已愈合。放置胃管取30分钟胃液标本,测定其胃粘蛋白成分,再按照公式:B/A+B×100测定粘膜保护指数(A=酸性粘蛋白复合物,B=中性糖蛋白复性物g/l,后者包括大部分碳水化合物)。病人随机地分为两组,两组的年龄、性别、病程和吸烟习惯等都类同。鉴于生胃酮有可能出现副作用,凡有高血压、心力衰竭、肾功能衰竭和肝硬化等病者均除外。第1组30例,每
Although many controlled trials have shown that cimetidine is a highly effective drug for the treatment of ulcers, the rate of ulcer recurrence is as much as 70-90% a few weeks or months after the cure. The authors cetuximab cured patients continue to use cimetidine or carbonic anhydroglycerin maintenance treatment, in order to compare the two drugs effect. Outpatient duodenal ulcer patients a total of 60 cases, aged 19 to 58 years. Application of cimetidine 1g / day, taken continuously for 4 or 6 weeks, confirmed by endoscopy ulcers have healed. Gastric tube was placed for 30 minutes to determine the content of gastric mucin, and the mucosal protective index was determined according to the formula: B / A + B × 100 (A = acidic mucin complex, B = neutral glycoprotein renaturation g / l, the latter includes most of the carbohydrates). Patients were randomly divided into two groups, the two groups of age, gender, duration and smoking habits are the same. Given the potential side effects of ketoconazole, patients with hypertension, heart failure, renal failure and cirrhosis are excluded. The first group of 30 cases, each