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气压定具有明显的降血压作用,其详细机理迄未阐明。Farsang(1979)曾报告,在自发性高血压大鼠,氯压定的降压作用可被阿片受体阻断剂纳洛酮(外周给药)所部分阻断。我们发现将纳洛酮或β-内啡肽抗体注入正常血压大鼠的脑室。可部分阻断氯压定的中枢性降压作用。 用170～250克大鼠,在戊巴比妥钠麻醉下行气管插管和双侧侧脑室瘘管植入术,从右颈总动脉插管经水银检压计或换能器记录动脉平均血压,经心电仪记录心率。实验中经脑管瘘管注入的药物有:(1)氯压定,每侧0.5μg/5μl,(2)纳洛酮,每侧50μg/5/μl,(3)抗β-内啡肽丙种免疫球蛋白(β-
Pressure set has obvious antihypertensive effect, the detailed mechanism has not been elucidated. Farsang (1979) reported that in spontaneously hypertensive rats, the antihypertensive effect of clonidine was partially blocked by naloxone (peripheral administration), an opioid receptor blocker. We found that injecting naloxone or beta-endorphin antibodies into the ventricles of normotensive rats. Can be partially blocked chlorine pressure set central antihypertensive effect. 170 to 250 grams of rats were anesthetized with sodium pentobarbital tracheal intubation and bilateral lateral ventricle fistula implantation, the right common carotid artery by mercury mercury or pressure transducer recording average arterial blood pressure, The heart rate monitor heart rate. (1) Clonazepam, 0.5 μg / 5 μl on each side, (2) naloxone, 50 μg / 5 μl on each side, (3) anti-β-endorphin Immunoglobulin (β-