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(上接08年3期特别关注栏目)HPAI与大流行的毒力禽流感病毒的毒力主要取决于病毒粒子的复制速度和HA蛋白切割位点附近的氨基酸组成。HA是位于流感病毒表面的一种重要的糖蛋白,在转录后首先表达为无活性的前体HAO,然后,通过蛋白酶水解,强毒株的HA被切割为两个有活性的多肽亚单位HA1和HA2,而弱毒株的HA则不被切
(Continued from 2008, 3 special attention section) HPAI and pandemic virulence The virulence of the avian influenza virus mainly depends on the speed of replication of the virus particles and amino acid composition near the HA protein cleavage site. HA is an important glycoprotein located on the surface of influenza virus and is first expressed as an inactive precursor HAO after transcription. Then, HA of the virulent strain is cleaved into two active polypeptide subunits HA1 by protease hydrolysis And HA2, while attenuated strains of HA are not cut